HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Cyanophenylacetic acid → 2-(4-Cyano-phenyl)-N-{5-[7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-pyridin-3-yl}-acetamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Cyanophenylacetic acid | HCID 79587 | — |
| Edukt | (5-aminopyridin-3-yl)(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone | HCID 70817536 | — |
| Produkt | 2-(4-Cyano-phenyl)-N-{5-[7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]-pyridin-3-yl}-acetamide | HCID 70817932 | — |
Reaktionsschritte
The title compound was prepared according to the method described for Example 1 using (5-Amino-pyridin-3-yl)-[7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-methanone (Preparation 103) and 4-cyanophenylacetic acid to afford the title compound as an off-white solid in 71% yield, 235 mg.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846698B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-b4d4244808f84799bf5c9fa1cc61aa78 |
| Quellennotiz | uspto-grants-2014_09 |