Hydrochloric Acid → 3-Amino-2-chloro-4-methylpyridine

HRID 82551

Reaktionsgleichung

Reaktionsgleichung von HRID 82551
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH2:8].[ClH:9].OO.C([O-])([O-])=O.[K+].[K+]>>[Cl:9][C:4]1[C:3]([NH2:8])=[C:2]([CH3:1])[CH:7]=[CH:6][N:5]=1

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 1379353-Amino-4-picoline

Produkt 1

HCID 27563873-Amino-2-chloro-4-methylpyridine

Versuchsvorschrift

A mixture of 4-methylpyridin-3-amine (0.62 g), 12N hydrogen chloride (3.8 mL) and 30% hydrogen peroxide (0.75 mL) was stirred at 0° C. to room temperature for 1 h. The mixture was neutralized with K2CO3, and the mixture was extracted with AcOEt. The organic layer was dried over MgSO4, and concentrated in vacuo to give 2-chloro-4-methylpyridin-3-amine (0.75 g) as an orange solid.

Aufarbeitung

  1. extractionthe mixture was extracted with AcOEt
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-489da6a3a71449b29daba86270409920
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846713B2

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