Methyl iodide → HCID 178503348, Verbindung

HRID 82574

Reaktionsgleichung

Reaktionsgleichung von HRID 82574
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]1[SH:10].CI.[C:13]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:13][S:10][C:2]1[NH:3][C:4]2=[N:5][CH:6]=[CH:7][CH:8]=[C:9]2[N:1]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178527819HCID 178527819, Verbindung

Produkt 1

HCID 178503348HCID 178503348, VerbindungAusbeute 45,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a solution of 1H-imidazo[4,5-b]pyridine-2-thiol (2 g) in acetone (30 mL) were added MeI (0.910 ml) and K2CO3 (5.48 g) at room temperature. After stirring for 10 h, the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (NH-silica gel, eluted with 10%-100% EtOAc in hexane) to give 2-(methylsulfanyl)-3H-imidazo[4,5-b]pyridine (1.0 g) as a white solid.

Aufarbeitung

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customThe residue was purified by column chromatography (NH-silica gel, eluted with 10%-100% EtOAc in hexane)

Quellen und Nachweise

ORD-Eintrag
ord-552e96a795fb4545bccf28eb5db15d6d
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846713B2

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