N-Methylbenzylamine → HCID 58577265, Verbindung
Reaktionsgleichung
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl[C:11]1[C:12]([N+:17]([O-:19])=[O:18])=[N:13][CH:14]=[CH:15][CH:16]=1>>[CH2:3]([N:2]([CH3:1])[C:11]1[C:12]([N+:17]([O-:19])=[O:18])=[N:13][CH:14]=[CH:15][CH:16]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
The mixture of N-methylbenzylamine (6.085 mL), TEA (13.19 ml) and 3-chloro-2-nitropyridine (5 g) was stirred at 60° C. under N2 overnight. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with 0%-30% EtOAc in hexane) to give N-benzyl-N-methyl-2-nitropyridin-3-amine (2.6 g) as dark yellow oil.
Aufarbeitung
- concentrationThe reaction mixture was concentrated in vacuo
- customThe residue was purified by column chromatography (silica gel, eluted with 0%-30% EtOAc in hexane)