Sodium hydride → (S)-2-((1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzonitrile

HRID 82771

Reaktionsgleichung

Reaktionsgleichung von HRID 82771
F[C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=1[C:4]#[N:5].[H-].[Na+].[CH3:16][N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[CH2:22][OH:23]>O1CCCC1>[CH3:16][N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[CH2:22][O:23][C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=1[C:4]#[N:5]

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 5210162-Fluoro-5-(trifluoromethyl)benzonitrileHCID 643492(2S)-1-Methyl-2-pyrrolidinemethanol

Produkt 1

HCID 66643250(S)-2-((1-methylpyrrolidin-2-yl)methoxy)-5-(trifluoromethyl)benzonitrileAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2-fluoro-5-(trifluoromethyl)benzonitrile (8.0 g, 42.3 mmol, Aldrich) in tetrahydrofuran (50 mL) were added sodium hydride (1.9 g, 46.5 mmol) and (S)-(1-methylpyrrolidin-2-yl)methanol (5.5 mL, 46.5 mmol, Aldrich). After stirring at room temperature for 3 hours, the reaction mixture was quenched with saturated NaHCO3 (30 mL). The aqueous layer was extracted with ethyl acetate (3×30 mL). The combined organic layers were washed with brine (50 mL), dried Na2SO4, filtered and concentrated under reduced pressure to afford 12.0 g (100%) of the title compound. LCMS (APCI+) m/z 285 (M+H)+.

Aufarbeitung

  1. customthe reaction mixture was quenched with saturated NaHCO3 (30 mL)
  2. extractionThe aqueous layer was extracted with ethyl acetate (3×30 mL)
  3. washThe combined organic layers were washed with brine (50 mL), dried Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1969248d43434f2388433f200e2ac6ed
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846730B2

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