Nitrogen → HCID 67958123, Verbindung

HRID 82838Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 82838
N#N.[Cl:3][CH2:4][C:5]1[O:6][CH:7]=[C:8]([CH2:10][OH:11])[N:9]=1.[CH3:12]I>C(Cl)Cl>[Cl:3][CH2:4][C:5]1[O:6][CH:7]=[C:8]([CH2:10][O:11][CH3:12])[N:9]=1

Komponenten

5

Edukt 3

HCID 947NitrogenHCID 6328Methyl iodideHCID 67958068(2-(Chloromethyl)oxazol-4-yl)methanol

Produkt 1

HCID 67958123HCID 67958123, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of (2-(chloromethyl)oxazol-4-yl)methanol (8.00 g, 54.22 mmol) in CH2Cl2 (32.0 mL) was treated with MeI (4.05 mL, 65.06 mmol) followed by Ag2O (18.85 g, 81.32 mmol) and the resulting mixture (protected from light) was stirred overnight at 40° C. The reaction mixture was filtered and the solvent was removed under reduced pressure. Purification of the residue by FC (6:4 hept-EA) gave the title compound as a yellow oil: TLC: rf (6:4 hept-EA)=0.31. LC-MS-conditions 07: tR=0.54 min, [M+H]+=162.00.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent was removed under reduced pressure
  3. customPurification of the residue by FC (6:4 hept-EA)

Quellen und Nachweise

ORD-Eintrag
ord-4b5f3d8df14e4c57b6688740bca9f124
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846733B2

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