Hydrochloric Acid → 3-pyrrolidin-3-yloxypyridine:hydrochloride

HRID 82940Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 82940
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][CH:8]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)[CH:2]=1.[ClH:20]>ClCCl.O1CCOCC1>[ClH:20].[NH:10]1[CH2:11][CH2:12][CH:8]([O:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:9]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 10801570tert-Butyl 3-(pyridin-3-yloxy)pyrrolidine-1-carboxylate

Produkt 1

HCID 534092893-pyrrolidin-3-yloxypyridine:hydrochlorideAusbeute 58 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a cooled solution of tert-butyl 3-(pyridin-3-yloxy)pyrrolidine-1-carboxylate (600 mg, 2.27 mmol; which may be prepared as described in Step 1) in dichloromethane (15 mL) was added dropwise HCl 4N in dioxane (11.1 mL). The solution was warmed to room temperature and stirred for 1 h. The solvent was evaporated under reduced pressure to give the title compound (263 mg, 58%) as a yellow wax.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e01fe83dae154b26a679d904e99d3f51
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846711B2

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