Trifluoroacetic acid → 2-[(2R)-Pyrrolidin-2-yl]-1,3-benzoxazole trifluoroacetate

HRID 82947

Reaktionsgleichung

Reaktionsgleichung von HRID 82947
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[O:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[C@H:17]1[CH2:21][CH2:20][CH2:19][N:18]1C(OC(C)(C)C)=O>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:18]1[CH2:19][CH2:20][CH2:21][C@@H:17]1[C:9]1[O:8][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[N:10]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68338089tert-Butyl (2R)-2-(1,3-benzoxazol-2-yl)pyrrolidine-1-carboxylate

Produkt 1

HCID 709267682-[(2R)-Pyrrolidin-2-yl]-1,3-benzoxazole trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In a 16 mL flask, trifluoroacetic acid (4 mL) was added to a mixture of tert-butyl (2R)-2-(1,3-benzoxazol-2-yl)pyrrolidine-1-carboxylate (88 mg, 0.31 mmol; which may be prepared as described in Step 2) dissolved in dichloromethane (4 mL) at 0° C. under nitrogen. The reaction was allowed to warm to room temperature and stirred for 3 h. The reaction mixture was concentrated to dryness and the residue used in the next step without further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated to dryness
  2. customthe residue used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-acc5cbbf046b490390760078f9c588a7
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846711B2

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