HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethanamine, 2-fluoro-, hydrochloride → N-(2-Fluoro-ethyl)-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethanamine, 2-fluoro-, hydrochloride | HCID 9995 | — |
| Edukt | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 66599213 | — |
| Produkt | N-(2-Fluoro-ethyl)-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide | HCID 57519923 | 95% |
Reaktionsschritte
As described for example 8b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using 2-fluoroethylamine hydrochloride instead of methylamine, to the title compound (109 mg, 95%) which was obtained as a white solid. MS: m/e=356.3 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846719B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-bf5efacb606c4a9fa08bb6003b6ed2f1 |
| Quellennotiz | uspto-grants-2014_09 |