2,2,3,3,3-Pentafluoropropylamine → 6-[3-(2-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,3,3,3-pentafluoro-propyl)-nicotinamide

HRID 83197

Reaktionsgleichung

Reaktionsgleichung von HRID 83197
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[F:24])=[N:14][O:15][C:16]=2[CH3:17])=[N:6][CH:5]=1.[F:26][C:27]([F:34])([C:30]([F:33])([F:32])[F:31])[CH2:28][NH2:29]>>[F:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:13]1[C:12]([CH2:11][O:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([NH:29][CH2:28][C:27]([F:34])([F:26])[C:30]([F:33])([F:32])[F:31])=[O:2])=[CH:5][N:6]=2)=[C:16]([CH3:17])[O:15][N:14]=1

Komponenten

3

Edukt 2

HCID 790022,2,3,3,3-PentafluoropropylamineHCID 684455236-[3-(2-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

Produkt 1

HCID 426290756-[3-(2-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-N-(2,2,3,3,3-pentafluoro-propyl)-nicotinamideAusbeute 75 %

Versuchsvorschrift

As described for example 84f, 6-[3-(2-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (100 mg, 0.292 mmol) was converted, using 2,2,3,3,3-pentafluoropropylamine instead of 2,2,2-trifluoroethylamine, to the title compound (100 mg, 75%) which was obtained as a white solid. MS: m/e=460.1 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-856536c7345b476890ff06947ffe1796
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846719B2

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