4-Hydroxypyrrolidine → (3-Hydroxy-pyrrolidin-1-yl)-[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-methanone

HRID 83339

Reaktionsgleichung

Reaktionsgleichung von HRID 83339
CO[C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:14][O:15][C:16]=2[CH3:17])=[N:6][CH:5]=1.[NH:25]1[CH2:29][CH2:28][CH:27]([OH:30])[CH2:26]1>>[OH:30][CH:27]1[CH2:28][CH2:29][N:25]([C:3]([C:4]2[CH:5]=[N:6][C:7]([O:10][CH2:11][C:12]3[C:13]([C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)=[N:14][O:15][C:16]=3[CH3:17])=[CH:8][CH:9]=2)=[O:24])[CH2:26]1

Komponenten

3

Edukt 2

HCID 982104-HydroxypyrrolidineHCID 665992926-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester

Produkt 1

HCID 57520375(3-Hydroxy-pyrrolidin-1-yl)-[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-methanoneAusbeute 87 %

Versuchsvorschrift

As described for example 220, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (120 mg, 0.37 mmol) was converted, using 3-pyrrolidinol instead of 3-amino-1-propanol, to the title compound (122 mg, 87%) which was obtained as a colourless oil. MS: m/e=380.3 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-bd6fd7b3713c44ddb66af5fc948c16ef
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846719B2

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