Acetaldehyde ammonia → (2-Hydroxy-ethyl)-6-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide

HRID 83393

Reaktionsgleichung

Reaktionsgleichung von HRID 83393
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=1.ClC1C=C(C2C(COC3C=CC(C(O)=O)=CN=3)=C(C)ON=2)C=CC=1.[NH2:48][CH:49]([OH:51])[CH3:50]>>[OH:20][CH2:19][CH2:18][C:17]1[N:16]=[C:15]([O:14][CH2:13][C:3]2[C:4]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=3)=[N:5][O:6][C:2]=2[CH3:1])[CH:23]=[CH:22][C:50]=1[C:49]([NH2:48])=[O:51]

Komponenten

4

Edukt 3

HCID 522583Acetaldehyde ammoniaHCID 426301706-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acidHCID 684448596-[3-(3-Chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid

Produkt 1

HCID 68442696(2-Hydroxy-ethyl)-6-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamideAusbeute 24 %

Versuchsvorschrift

As described for example 98b, 6-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid (77.8 mg, 0.25 mmol) was converted, instead of 6-[3-(3-chloro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid, using aminoethanol instead of 2,2,2-trifluoroethylamine, to the title compound (21 mg, 24%) which was obtained as a white solid. MS: m/e=355.0 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-b93f78311ae0403aa30e9709284440fc
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846719B2

Verknüpfte Notizen

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