Trifluoroacetic acid → HCID 86680360, Verbindung

HRID 83519Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 83519
C([O:5][C:6]([C@H:8]1[CH2:12][NH:11][C:10](=[O:13])[N:9]1[CH3:14])=[O:7])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[CH3:14][N:9]1[C@@H:8]([C:6]([OH:7])=[O:5])[CH2:12][NH:11][C:10]1=[O:13]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86680358(R)-3-Methyl-2-oxoimidazolidine-4-carboxylic Acid tert-butyl Ester

Produkt 1

HCID 86680360HCID 86680360, VerbindungAusbeute 76,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of (R)-3-methyl-2-oxoimidazolidine-4-carboxylic acid tert-butyl ester (94 mg) in chloroform (2 ml) was added trifluoroacetic acid (1 ml) at room temperature, and the mixture was stirred for 3 hours. This reaction solution was concentrated under reduced pressure, additional toluene (3 ml) was added thereto, and the mixture was again concentrated. To the resulting residue was added diethyl ether (0.5 ml) at room temperature, and the mixture was stirred. Next, n-hexane (2 ml) was added thereto, and the mixture was further stirred. The insoluble substance was collected by filtration, and dried under reduced pressure to give the titled compound (52 mg).

Aufarbeitung

  1. concentrationThis reaction solution was concentrated under reduced pressure, additional toluene (3 ml)
  2. additionwas added
  3. concentrationthe mixture was again concentrated
  4. additionTo the resulting residue was added diethyl ether (0.5 ml) at room temperature
  5. stirringthe mixture was stirred
  6. additionNext, n-hexane (2 ml) was added
  7. filtrationThe insoluble substance was collected by filtration
  8. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bca779d571af4ab59a57660b8c9f29b6
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846746B2

Notizen zur Reaktion

Wird geladen…