2,4-Dimethoxybenzylamine → HCID 71287769, Verbindung

HRID 83583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 83583
CO[C:3]([C:5]1([C:8]([C:10]([O:12][CH3:13])=[O:11])=[CH2:9])[CH2:7][CH2:6]1)=[O:4].[CH3:14][O:15][C:16]1[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:17]=1[CH2:18][NH2:19]>C1(C)C=CC=CC=1>[CH3:13][O:12][C:10]([CH:8]1[C:5]2([CH2:6][CH2:7]2)[C:3](=[O:4])[N:19]([CH2:18][C:17]2[CH:20]=[CH:21][C:22]([O:24][CH3:25])=[CH:23][C:16]=2[O:15][CH3:14])[CH2:9]1)=[O:11]

Komponenten

4

Edukt 2

HCID 5972502,4-DimethoxybenzylamineHCID 866803911-(1-Methoxycarbonylvinyl)cyclopropanecarboxylic Acid Methyl Ester

Produkt 1

HCID 71287769HCID 71287769, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 1-(1-methoxycarbonylvinyl)cyclopropanecarboxylic acid methyl ester (720 mg) in toluene (3.6 ml) was added 2,4-dimethoxybenzylamine (587 μl) at room temperature, and then the mixture was stirred at reflux for 20 hours. This reaction mixture was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1) to give the titled compound (567 mg).

Aufarbeitung

  1. temperatureat reflux for 20 hours
  2. concentrationThis reaction mixture was concentrated under reduced pressure
  3. customthe resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1)

Quellen und Nachweise

ORD-Eintrag
ord-c90155ae579c439c8ebb8b7b6b0a8244
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846746B2

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