1-(4-Methoxyphenyl)cyclopropane-1-carboxylic acid → Methyl 1-(4-methoxyphenyl)-cyclopropanecarboxylate

HRID 83695

Reaktionsgleichung

Reaktionsgleichung von HRID 83695
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([OH:14])=[O:13])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.O.[C:16]1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH3:16][O:13][C:12]([C:9]1([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[CH2:10][CH2:11]1)=[O:14]

Komponenten

4

Edukt 2

HCID 855751-(4-Methoxyphenyl)cyclopropane-1-carboxylic acidHCID 521998p-Toluenesulfonic acid monohydrate

Produkt 1

HCID 13707544Methyl 1-(4-methoxyphenyl)-cyclopropanecarboxylateAusbeute 1.980,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1-(4-methoxy-phenyl)-cyclopropanecarboxylic acid (50.0 g, 0.26 mol) in MeOH (500 mL) was added toluene-4-sulfonic acid monohydrate (2.5 g, 13.1 mmol) at room temperature. The reaction mixture was heated at reflux for 20 hours. MeOH was removed by evaporation under vacuum and EtOAc (200 mL) was added. The organic layer was washed with sat. aq. NaHCO3 (100 mL) and brine, dried over anhydrous Na2SO4 and evaporated under vacuum to give 1-(4-methoxy-phenyl)-cyclopropanecarboxylic acid methyl ester (53.5 g, 99%). 1H NMR (CDCl3, 400 MHz) δ 7.25-7.27 (m, 2H), 6.85 (d, J=8.8 Hz, 2H), 3.80 (s, 3H), 3.62 (s, 3H), 1.58 (q, J=3.6 Hz, 2H), 1.15 (q, J=3.6 Hz, 2H).

Aufarbeitung

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 20 hours
  3. customMeOH was removed by evaporation under vacuum and EtOAc (200 mL)
  4. additionwas added
  5. washThe organic layer was washed with sat. aq. NaHCO3 (100 mL) and brine
  6. dry with materialdried over anhydrous Na2SO4
  7. customevaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-44b78acd95c0426cb5d8652d5eb7692a
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846753B2

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