Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride

HRID 83774

Reaktionsgleichung

Reaktionsgleichung von HRID 83774
C([O:3][C:4](=[O:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=1)C.[ClH:18]>>[ClH:18].[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:12][CH:11]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 309738Ethyl 2-(4-acetamidophenoxy)acetate

Produkt 1

HCID 668114882-(4-Aminophenoxy)acetic acid hydrochlorideAusbeute 77,6 %

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2 (250 g, 77.6%) as a wheat colored powder.

Aufarbeitung

  1. distillationExcess concentrated Hydrochloric acid was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9069b2e2cf384531903fee23e517008c
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846845B2

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