Hydrochloric Acid → HCID 66811347, Verbindung

HRID 83787

Reaktionsgleichung

Reaktionsgleichung von HRID 83787
C[O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]C(=O)C)=[CH:12][CH:11]=1.[ClH:21]>>[ClH:21].[NH2:16][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:20])=[O:2])=[CH:15][CH:14]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 497644916-(4-Acetylaminophenoxy)-hexanoic acid methyl ester

Produkt 1

HCID 66811347HCID 66811347, VerbindungAusbeute 55,6 %

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

6-(4-acetylaminophenoxy)-hexanoic acid methyl ester 15 (290 g, 1.04 mol), in conc. HCl (7.12 L) was refluxed for 48 hours. Excess conc. HCl was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 16 (150 g, 55.6%) as a brown powder with an m.p between 155-160° C.

Aufarbeitung

  1. distillationExcess conc. HCl was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-93b05adb289b4ef4b46a331de0d6996f
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08846845B2

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