Methyl iodide → Oxoglaucine methiodide

HRID 838930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 838930
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[C:11]2[C:15]3[C:20]([C:21](=[O:22])[C:9]4=[C:10]2[C:5](=[CH:6][CH:7]=[N:8]4)[CH:4]=1)=[CH:19][C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3.[I:27][CH3:28]>CC(C)=O>[CH3:28][N+:8]1[CH:7]=[CH:6][C:5]2[C:10]3=[C:11]([C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=2)[C:15]2[C:20]([C:21](=[O:22])[C:9]=13)=[CH:19][C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=2.[I-:27]

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 97662Oxoglaucine2×

Produkt 1

HCID 41680Oxoglaucine methiodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Oxoglaucine methiodide was prepared from oxoglaucine in accordance with the process of Example V. A 31 mg sample of oxoglaucine was refluxed in 8 ml of acetone until it completely dissolved (approximately 30 minutes) and then 0.75 ml of iodomethane was added. The solution was refluxed until it became brown. The crystals were then collected by filtration to yield 15 mg of the methiodide salt, mp 255 d.

Aufarbeitung

  1. dissolutioncompletely dissolved (approximately 30 minutes)
  2. temperatureThe solution was refluxed until it
  3. filtrationThe crystals were then collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-b882f16c4ef2405baf31e5f047788dca
Quelldatensatz
uspto-grants-1978_06
Patentnummer
US04093717

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