Methyl iodide → 2-[Acetyl(2,2-diethoxyethyl)amino]-1-methylpyridin-1-ium iodide

HRID 839616Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 839616
[CH2:1]([O:3][CH:4]([O:16][CH2:17][CH3:18])[CH2:5][N:6]([C:13](=[O:15])[CH3:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:2].[CH3:19][I:20]>C(O)C>[I-:20].[CH3:19][N+:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[N:6]([C:13](=[O:15])[CH3:14])[CH2:5][CH:4]([O:16][CH2:17][CH3:18])[O:3][CH2:1][CH3:2]

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 20323729HCID 20323729, Verbindung

Produkt 1

HCID 203237172-[Acetyl(2,2-diethoxyethyl)amino]-1-methylpyridin-1-ium iodideAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of N-acetyl-N-(2-pyridyl)-aminoacetaldehyde diethyl acetal (6.0 g.), methyl iodide (25 g.) and ethanol (30 ml.) was heated for 15 hours at 60° C in a sealed tube. The reaction mixture was concentrated and water was added to the residual oil. The mixture was washed twice with ether and the aqueous layer was concentrated under reduced pressure to give oil of 1-methyl-2-[N-acetyl-N-(2,2-diethoxyethyl)-amino]-pyridinium iodide (9.0 g.).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. additionwater was added to the residual oil
  3. washThe mixture was washed twice with ether
  4. concentrationthe aqueous layer was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2e73f7b8b5a2407cbc17f05f6a155811
Quelldatensatz
uspto-grants-1978_06
Patentnummer
US04096263

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