Dimethylformamide → 4-[8-CHLORO-5,6-DIHYDRO-4-[(2-METHYL-2H-TETRAZOL-5-YL)THIO]-11H-BENZO[5,6]CYCLOHEPTA[1,2-b]PYRIDIN-11-YLIDENE]-1-(3-PYRIDINYLACETYL)-PIPERIDINE

HRID 840278

Reaktionsgleichung

Reaktionsgleichung von HRID 840278
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:32])[CH2:25][C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH2:20][CH2:19]3)[C:9]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:10]=3[CH2:11][CH2:12][C:3]=12.[Na].[SH:34][C:35]1[N:39](C)[N:38]=[N:37][N:36]=1.[CH3:41]N(C=O)C>>[Cl:17][C:14]1[CH:15]=[CH:16][C:9]2[C:8](=[C:18]3[CH2:23][CH2:22][N:21]([C:24](=[O:32])[CH2:25][C:26]4[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=4)[CH2:20][CH2:19]3)[C:4]3=[N:5][CH:6]=[CH:7][C:2]([S:34][C:35]4[N:39]=[N:38][N:37]([CH3:41])[N:36]=4)=[C:3]3[CH2:12][CH2:11][C:10]=2[CH:13]=1

Komponenten

4

Edukt 3

HCID 6228DimethylformamideHCID 226219554-[4,8-Dichloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-b]Pyridin-11-Ylidene]-1-(3-Pyridinylacetyl)-PiperidineHCID 178482029HCID 178482029, Verbindung

Produkt 1

HCID 226219564-[8-CHLORO-5,6-DIHYDRO-4-[(2-METHYL-2H-TETRAZOL-5-YL)THIO]-11H-BENZO[5,6]CYCLOHEPTA[1,2-b]PYRIDIN-11-YLIDENE]-1-(3-PYRIDINYLACETYL)-PIPERIDINEAusbeute 68 %

Versuchsvorschrift

A mixture of the title compound from Example 250 (0.24 grams), 5-mercapto-1-methyltetrazole sodium salt (0.6 grams) and anhydrous DMF (10 mL) was stirred while being irradiated with a 200 W lamp for 10 days. Isolation and purification as in Example 257 provided the title compound (0.2 grams, 68%, MH+ 544).

Aufarbeitung

  1. customwhile being irradiated with a 200 W lamp for 10 days
  2. customIsolation and purification as in Example 257

Quellen und Nachweise

ORD-Eintrag
ord-77d5aad56bc64abea7a80ac1cdff9910
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06365588B1

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