Desipramine Hydrochloride → Desipramine

HRID 840510

Reaktionsgleichung

Reaktionsgleichung von HRID 840510
[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][N:6]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[CH2:14][CH2:13][C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]1=2.Cl>[OH-].[Na+]>[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][N:6]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]1=2

Komponenten

3

Edukt 1

HCID 65327Desipramine Hydrochloride

Produkt 1

HCID 2995DesipramineAusbeute 99,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To 6.02 g of desipramine hydrochloride was added 150 ml of 1N NaOH. The mixture was allowed to stir for 10 minutes. The aqueous mixture was extracted with 6×100 ml of chloroform. The combined chloroform layer was washed with 200 ml of water. The organic part was dried (Na2SO4) and concentrated to give 5.25 g of desipramine free base.

Aufarbeitung

  1. extractionThe aqueous mixture was extracted with 6×100 ml of chloroform
  2. washThe combined chloroform layer was washed with 200 ml of water
  3. dry with materialThe organic part was dried (Na2SO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-78cbff80e04c44a7a384b30c58aff007
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06368814B1

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