Glycol monopropyl ether → HCID 18461246, Verbindung

HRID 840657Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 840657
[CH2:1]([O:4][CH2:5][CH2:6][OH:7])[CH2:2][CH3:3].CC(C)([O-])C.[K+].F[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[N:16]=1>C1COCC1.[Cl-].[Na+].O>[F:21][C:17]1[CH:18]=[CH:19][CH:20]=[C:15]([O:7][CH2:6][CH2:5][O:4][CH2:1][CH2:2][CH3:3])[N:16]=1

Komponenten

6

Edukt 3

HCID 17756Glycol monopropyl etherHCID 739342,6-DifluoropyridineHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 18461246HCID 18461246, VerbindungAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittel2×HCID 57417360Sodium chloride; waterLösungsmittel

Versuchsvorschrift

2-Propoxyethanol (1.89 g, 18.1 mmol) was dissolved in 50 mL THF, treated with potassium tert-butoxide (3.05 g, 27.2 mmol), stirred to uniform solution, placed in an addition funnel, and added dropwise to a solution of 2,6-difluoropyridine in 50 mL THF. After stirring overnight at room temperature, the solution was diluted with brine and extracted with ether. The ether extracts were combined and dried over Na2SO4, then concentrated in vacuo to yield 2-fluoro-6-(2-propoxyethoxy)-pyridine (3.33 g, 93%) as a yellow oil.

Aufarbeitung

  1. customplaced in an addition funnel
  2. stirringAfter stirring overnight at room temperature
  3. extractionextracted with ether
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-80151212ae704536ac7ba3170f3e6cca
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06369083B1

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