Potassium Carbonate → 6-(2-Amino-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-2-methyl-5-nitro-3H-pyrimidin-4-one

HRID 841014

Reaktionsgleichung

Reaktionsgleichung von HRID 841014
Br[C:2]1[N:7]=[C:6]([CH3:8])[NH:5][C:4](=[O:9])[C:3]=1[N+:10]([O-:12])=[O:11].[NH2:13][C:14]1[S:15][C:16]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18][C:17]=2[N:23]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[NH2:13][C:14]1[S:15][C:16]2[CH2:22][CH2:21][N:20]([C:2]3[N:7]=[C:6]([CH3:8])[NH:5][C:4](=[O:9])[C:3]=3[N+:10]([O-:12])=[O:11])[CH2:19][CH2:18][C:17]=2[N:23]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 1356171936-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one

Produkt 1

HCID 1356711606-(2-Amino-4,5,7,8-tetrahydro-thiazolo[4,5-d]azepin-6-yl)-2-methyl-5-nitro-3H-pyrimidin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

In analogy to the procedure described in example 1c 6-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one as prepared in example 1a was treated with 2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine [Ger. Offen. (1989), DE 3820775] in N,N-dimethylformamide in the presence of potassium carbonate at 110° C. to yield the title compound as yellow solid; m.p. >200° C.; MS: [M+H]+=323.

Aufarbeitung

  1. customas prepared in example 1a

Quellen und Nachweise

ORD-Eintrag
ord-22707a29666845449681b670d21f45e1
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06369222B1

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