HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Lithium Hydroxide → 1-benzenesulfonyl-1H-indole-5-carboxylic acid hydroxyamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Lithium Hydroxide | HCID 3939 | — |
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | Benzenesulfonyl chloride | HCID 7369 | — |
| Edukt | Benzyl Chloride | HCID 7503 | — |
| Edukt | PyBOP | HCID 2724699 | — |
| Edukt | O-(Tetrahydropyran-2-yl)hydroxylamine | HCID 5142091 | — |
| Edukt | Potassium tert-butoxide | HCID 23665647 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 1-benzenesulfonyl-1H-indole-5-carboxylic acid hydroxyamide | HCID 53464575 | — |
Reaktionsschritte
Compound 1 was synthesized via the route as shown in Scheme 1 above (reagents and conditions: a) benzyl chloride or benzenesulfonyl chloride, t-BuOK, KI, DMF; b) 1M LiOH(aq), dioxane; c) (i) NH2OTHP, PyBOP, NEt3, DMF, rt; (ii) TFA, MeOH, rt).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08846748B2 |
| Quelldatensatz | uspto-grants-2014_09 |
| ORD ID | ord-0920744fda3c4b1fb38ee5c46c52898b |
| Quellennotiz | uspto-grants-2014_09 |