3-Chlorophenylacetic acid → N-(3-chlorophenylacetyl)-2-hydroxy-3-bromo-5-chloroaniline
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[OH:12][C:13]1[C:19]([Br:20])=[CH:18][C:17]([Cl:21])=[CH:16][C:14]=1[NH2:15].C(N1C=CN=C1)(N1C=CN=C1)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH:15][C:14]2[CH:16]=[C:17]([Cl:21])[CH:18]=[C:19]([Br:20])[C:13]=2[OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1Komponenten
4
Versuchsvorschrift
Using the normal amide forming conditions, the condensation of 3-chlorophenylacetic acid (13.54 g, 0.079 mol) and 2-hydroxy-3-bromo-5-chloroaniline (17.7 g, 0.079 mol) with 1,1′-carbonyl diimidazole (13.5 g, 0.083 mol) gave the title compound (20 g).