Sodium Bicarbonate → Butylamide tetrasodium salt

Subsequently, to the above butylamide of S1 anhydride (160 mg) were added a sodium bicarbonate aqueous solution (NaHCOs 121 mg, water 20 mL) and 1,4-dioxane (20 mL), and the resultant was allowed to undergo a reaction at room temperature for 16 hours. After the reaction was completed, the solvent was removed under reduced pressure to afford butylamide tetrasodium salt of S1 compound (200 mg). The 1H-NMR and IR data of this compound were as shown below. From these data, the compound thus obtained was confirmed to be a derivative in which the carboxyl groups bonded to the saturated carbon atoms in the structural formula of S1 compound were butylamidated, while other carboxyl groups were substituted with sodium salt.

1. customa reaction at room temperature for 16 hours
2. customthe solvent was removed under reduced pressure

ORD-Eintrag

ord-9729af8d6dbf4140bf1b35289c31c8d7

Quelldatensatz

uspto-grants-2002_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06372943B1