Hydrochloric Acid → HCID 18727059, Verbindung

HRID 842772Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 842772
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N+:23]([O-:25])=[O:24])[CH2:13][CH2:12]1)(C)(C)C.Cl>C(OCC)(=O)C>[N+:23]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[N:14]1[CH2:13][CH2:12][CH:11]([NH:10][CH2:9][CH2:8][NH2:7])[CH2:16][CH2:15]1)([O-:25])=[O:24]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 18727100HCID 18727100, Verbindung

Produkt 1

HCID 18727059HCID 18727059, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 9 (576 mg, 1.66 mmol) in ethyl acetate (50 mL) was cooled to 0° C. and treated with anhydrous HCl (5 min). The mixture was. stirred at room temperature (2 h). The solvent was removed in vacuo and the residue disolved in dichloromethane and sodium carbonate solution. The aqueous layer was extracted with two additional portions of dichloromethane. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound (10). The crude product was used directly.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. extractionThe aqueous layer was extracted with two additional portions of dichloromethane
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fc068f8f6a98425c87c7912bb1ea067d
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06376503B1

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