Potassium Carbonate → Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

HRID 8429

Reaktionsgleichung

Reaktionsgleichung von HRID 8429
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].C(=O)([O-])[O-].[K+].[K+].CS(O[C@H:22]([CH3:27])[C:23]([O:25][CH3:26])=[O:24])(=O)=O>[Cl-].C([N+](CCCCCC)(CCCCCC)CCCCCC)CCCCC>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][C@@H:22]([CH3:27])[C:23]([O:25][CH3:26])=[O:24]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 774682,3,4-TrifluoroanilineHCID 57320743Methyl (2R)-2-[(methylsulfonyl)oxy]propanoate

Produkt 1

HCID 10125210Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80021Tetrahexylammonium chlorideKatalysator

Versuchsvorschrift

In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-2-[(methanesulfonyl)oxy]propionate (78 mg) and tetrahexylammonium chloride (40 mg) to give the title compound as an oily substance. As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 38 mg (24%) of the title compound.

Aufarbeitung

  1. customIn accordance with the process of Example 2, a condensation reaction

Quellen und Nachweise

ORD-Eintrag
ord-d9b0bffd894b426d850fcbbf6660c959
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07087778B2

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