Ethyl 4-bromobutyrate → Ethyl 4-phenoxybutanoate
Reaktionsgleichung
[O:1]1CCCC(=O)[C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.Br[CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[O:1]([CH2:14][CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:3]=1Komponenten
3
Versuchsvorschrift
Scheme 1 shows a general method for preparation of 3,4-dihydrobenzo[b]oxepin-5(2H)-one intermediates 66 by O-alkylation of a phenolic compound with ethyl 4-bromobutanoate to give a ethyl 4-phenoxybutanoate intermediate 67, followed by saponification to the carboxylic acid 68 and intramolecular cyclization under acidic conditions.
Quellen und Nachweise
- ORD-Eintrag
- ord-3f79208ddd564cc696278045e61effac
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08846762B2
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