[F:1][C:2]([F:11])([F:10])[C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[CH2:12](N(CC)CC)C.O1CCCC1.[S:24]1[C:28]2[C:29]3[CH:37]=[CH:36][CH:35]=[CH:34][C:30]=3[O:31][CH2:32][CH2:33][C:27]=2[CH:26]=[C:25]1[C:38](Cl)=[O:39].[H-].[Na+].CI>>[CH3:12][N:5]([C:4]1[CH:6]=[CH:7][CH:8]=[CH:9][C:3]=1[C:2]([F:10])([F:11])[F:1])[C:38]([C:25]1[S:24][C:28]2[C:29]3[CH:37]=[CH:36][CH:35]=[CH:34][C:30]=3[O:31][CH2:32][CH2:33][C:27]=2[CH:26]=1)=[O:39]To a solution of 2-(trifluoromethyl)aniline (0.122 g, 0.755 mmol) and triethylamine (0.105 mL, 0.756 mmol) in tetrahydrofuran (1.5 mL, 18 mmol) was added portion wise as a solid 4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carbonyl chloride (0.100 g, 0.378 mmol). The reaction mixture was stirred at room temperature with LC/MS monitor for formation of the alkylated product and noted complete after 2 hours. After aqueous work up, the reaction mixture was concentrated in vacuo, taken into DMF and treated with sodium hydride (0.03 g, 1 mmol) at room temperature for several minutes. Methyl iodide (0.06 g, 0.4 mmol) was added and the reaction was stirred at room temperature for several hours, then concentrated in vacuo. The residue was taken into EtOAc and washed with water and saline, concentrated to a solid residue, taken into DMF at a concentration of 100 mg/ml and purified by preparative RP-HPLC to give 130. Yield=25% of theoretical. MS: (ESI+) 404.1
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