1-Phenylcyclohexanecarbonitrile → (1-Phenylcyclohexyl)methanamine

HRID 845124Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 845124
[C:1]1([C:7]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Ni]>[C:1]1([C:7]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 1

HCID 751481-Phenylcyclohexanecarbonitrile

Produkt 1

HCID 205110(1-Phenylcyclohexyl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1-Phenylcyclohexane carbonitrile is reduced with H2 in methanol containing 16% ammonia with a Raney nickel catalyst. The catalyst is filtered off and (1-phenylcyclohexyl)methylamine is precipitated as its hydrochloride salt m.p. 230°-33° C., by treatment with methanolic HCl and isopropyl ether.

Aufarbeitung

  1. filtrationThe catalyst is filtered off
  2. custom(1-phenylcyclohexyl)methylamine is precipitated as its hydrochloride salt m.p. 230°-33° C., by treatment with methanolic HCl and isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-22684cdcfb2a427dbdacba43284a77b9
Quelldatensatz
uspto-grants-1988_07
Patentnummer
US04755594

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