Benzaldehyde → 1-Cyclohexyl-4-dimethylamino-2-phenyl-2-buten-1-ol

HRID 845146Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 845146
C(C1C=C(C(C)C)C=C(C(C)C)C=1S(NN=[C:21]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:22][CH2:23][N:24]1[CH2:28]CC[CH2:25]1)(=O)=O)(C)C.[CH:35](=[O:42])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH:36]1([CH:35]([OH:42])[C:21]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[CH:22][CH2:23][N:24]([CH3:25])[CH3:28])[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1

Komponenten

3

Edukt 2

HCID 240BenzaldehydeHCID 86741731beta-(1-Pyrrolidinyl)propiophenone 2,4,6-triisopropylbenzenesulphonylhydrazone

Produkt 1

HCID 538458471-Cyclohexyl-4-dimethylamino-2-phenyl-2-buten-1-ol

Versuchsvorschrift

By using a method similar to that described in Example 22, but starting from β-(1-pyrrolidinyl)propiophenone 2,4,6-triisopropylbenzenesulphonylhydrazone (20 g), and benzaldehyde (4.6 cc), 1,2-diphenyl-4-(1-pyrrolidinyl)-2-buten-1-ol (Z) hydrochloride (9.9 g) is obtained, after recrystallisation from a mixture of 2-propanol and isopropyl ether (40/60 by volume), in the form of white crystals melting at 106° C.

Quellen und Nachweise

ORD-Eintrag
ord-d473b8c44a544c938c168c1c23e1cfc5
Quelldatensatz
uspto-grants-1988_07
Patentnummer
US04755599

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