Isopropanol → 1-(3-Methoxypyridin-2-yl)piperazine

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Reaktionsgleichung

Cl[C:2]1[C:7](C2C=CC=CC=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[CH:20]([OH:23])(C)C>>[CH3:20][O:23][C:7]1[C:2]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[N:3][CH:4]=[CH:5][CH:6]=1

Komponenten

Edukt 3

HCID 3776Isopropanol

HCID 4837Piperazine

HCID 27628072-Chloro-3-phenylpyridine

Produkt 1

HCID 127904951-(3-Methoxypyridin-2-yl)piperazine

Versuchsvorschrift

The 2-chloro-3-methoxypyridine (VI) was treated with piperazine in a refluxing isopropanol medium according to the procedure of Example 3 and, following a similar work-up, gave the desired IIIc intermmediate.

Aufarbeitung

customgave the desired IIIc intermmediate

Quellen und Nachweise

ORD-Eintrag: ord-1e2287df4af74832ae6c5bd4c80d62de
Quelldatensatz: uspto-grants-1988_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04757073

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