Sulfuric Acid → HCID 14698595, Verbindung

HRID 846208Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 846208
[C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:22])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])#[N:2].S(=O)(=O)(O)[OH:24]>>[NH2:2][C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:22])[C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])=[O:24]

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 14698596HCID 14698596, Verbindung

Produkt 1

HCID 14698595HCID 14698595, Verbindung

Versuchsvorschrift

5 g. N-[4-(1-Cyano-1-methylethyl)-phenyl]-4-methoxybenzamide (Example 27) are stirred for 20 hours at ambient temperature in 100 ml. concentrated sulphuric acid, poured on to ice, the precipitate is filtered off with suction, dissolved in hot glacial acetic acid, water added thereto until the commencement of turbidity and then left to cool. There are obtained 2.2 g. (42% of theory) of the title compound in the form of colourless crystals; m.p. 234°-235° C.

Aufarbeitung

  1. filtrationthe precipitate is filtered off with suction
  2. dissolutiondissolved in hot glacial acetic acid
  3. additionwater added
  4. waituntil the commencement of turbidity and then left
  5. temperatureto cool
  6. customThere are obtained 2.2 g

Quellen und Nachweise

ORD-Eintrag
ord-f5e27edd7b3046fc8b07123cd5c28b19
Quelldatensatz
uspto-grants-1992_08
Patentnummer
US05135949

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