Propargyl bromide → HCID 15065591, Verbindung

HRID 846649Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 846649
[CH2:1](Br)[C:2]#[CH:3].[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH2:10])[CH3:6].[CH2:14]1[CH2:18]OC[CH2:15]1>>[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][N:10]([CH2:18][C:14]#[CH:15])[CH2:1][C:2]#[CH:3])[CH3:6].[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH:10][CH2:1][C:2]#[CH:3])[CH3:6]

Komponenten

5

Edukt 3

HCID 7842Propargyl bromideHCID 8028TetrahydrofuranHCID 695242,2-Diethoxyethylamine

Produkt 2

HCID 15065591HCID 15065591, VerbindungHCID 15065592HCID 15065592, Verbindung

Versuchsvorschrift

Propargyl bromide (14.7 g of 80% solution in toluene, 0.1 mol) was added to a stirred solution of aminoacetaldehyde diethyl acetal (13.3 g, 0.1 mol) in THF (200 mL). After 2 h the THF was removed and the residual oil was partitioned between ether and sodium hydroxide solution. Evaporation of the ether gave an oil which was chromatographed on silica gel to give 4.7 g of 2,2-diethoxy-N,N-bis-(2-propynyl)ethylamine and 8.1 g of 2,2-diethoxy-N-(2-propynyl)ethylamine.

Aufarbeitung

  1. customAfter 2 h the THF was removed
  2. customthe residual oil was partitioned between ether and sodium hydroxide solution
  3. customEvaporation of the ether
  4. customgave an oil which
  5. customwas chromatographed on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-3b138228e9f642d28b60a09a16aeb651
Quelldatensatz
uspto-grants-1992_08
Patentnummer
US05137905

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