Piperazine → 2-Methyl-4-(piperazin-1-yl)pyrimidine

HRID 846844Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 846844
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>O1CCCC1>[CH3:8][C:4]1[N:3]=[C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:7]=[CH:6][N:5]=1

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 4244474-Chloro-2-methylpyrimidine

Produkt 1

HCID 148385552-Methyl-4-(piperazin-1-yl)pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

13 g of 4-chloro-2-methyl-pyrimidine were dissolved in 200 ml of tetrahydrofuran, and 17.5 g of piperazine were added. The reaction mixture was refluxed for 24 h. The precipitated piperazine hydrochloride was filtered off with suction and washed with tetrahydrofuran. Concentration of the solution in vacuo resulted in 19 g of 2-methyl-4-piperazino-pyrimidine, which was reacted without further purification.

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed for 24 h
  2. filtrationThe precipitated piperazine hydrochloride was filtered off with suction
  3. washwashed with tetrahydrofuran
  4. customConcentration of the solution in vacuo resulted in 19 g of 2-methyl-4-piperazino-pyrimidine
  5. customwhich was reacted without further purification

Quellen und Nachweise

ORD-Eintrag
ord-1684b2b7aac043178849f16e01f9be81
Quelldatensatz
uspto-grants-1992_08
Patentnummer
US05138058

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