Ammonia → 7-Amino-3-(4,6-diamino-1,5-dimethyl-pyrimidinium-2-yl)thiomethyl-3-cephem-4-carboxylate

Temperatur

0 °C

Under an anhydrous condition, a solution containing 2.72 g of 3-acetoxymethyl-7-amino-3-cephem-4-carboxylic acid and 1.70 g of 4,6-diamino-1,5-dimethyl-2-(1H)-pyrimidinethione suspended in a mixture of 10 ml of dry acetonitrile and 10 ml of dioxane was cooled to 0° C.; and 4.8 ml of boron trifluoride diethylether was added. The temperature of the reaction solution was increased to 50° C.; the solution was stirred for five hours; and then 10 ml of methyl alcohol was added. The resultant solution was stirred for 10 minutes and was added with 30 ml of ice water. The pH of the solution was adjusted to 7.1 by adding aqueous ammonia solution After concentration under a reduced pressure, e.g., about 20 mmHg, the solution was adjusted to pH 3.7 with 2N-aqueous hydrochloric acid; and allowed to stand at a room temperature for 24 hrs. The precipitates resulted from the reaction solution were filtered, washed with 10 ml of distilled water and with 10 ml of methyl alcohol, and dried to give 3.02 g of the title compound as a solid.

1. temperatureThe temperature of the reaction solution was increased to 50° C.
2. concentrationAfter concentration under a reduced pressure, e.g., about 20 mmHg
3. waitto stand at a room temperature for 24 hrs
4. customThe precipitates resulted from the reaction solution
5. filtrationwere filtered
6. washwashed with 10 ml of distilled water and with 10 ml of methyl alcohol
7. customdried

ORD-Eintrag

ord-c660bd24e08146a89b789dc2d08b0196

Quelldatensatz

uspto-grants-1992_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05142041