Ethylenediamine → N-(2-Dimethylaminoethyl)-N'-[2-(2-benzimidazolylmethylamino)-ethyl]thiourea

HRID 847913

Reaktionsgleichung

[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[CH2:10][NH:11][CH2:12][CH2:13][NH2:14].C(N)CN.ClCC1NC2C=CC=CC=2N=1.[CH3:30][N:31]([CH3:37])[CH2:32][CH2:33][N:34]=[C:35]=[S:36]>>[CH3:30][N:31]([CH3:37])[CH2:32][CH2:33][NH:34][C:35]([NH:14][CH2:13][CH2:12][NH:11][CH2:10][C:2]1[NH:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1)=[S:36]

Komponenten

Edukt 4

HCID 3301Ethylenediamine

HCID 785712-Chloromethylbenzimidazole

HCID 3853726(2-Isothiocyanatoethyl)dimethylamine

HCID 15365342N1-((1H-Benzo[d]imidazol-2-yl)methyl)ethane-1,2-diamine

Produkt 1

HCID 54373380N-(2-Dimethylaminoethyl)-N'-[2-(2-benzimidazolylmethylamino)-ethyl]thiourea

Versuchsvorschrift

N-(2-Benzimidazolylmethyl)ethylenediamine, prepared by reacting ethylenediamine with 2-chloromethylbenzimidazole by the procedure of Example 40, is reacted with 2-dimethylaminoethyl isothiocyanate by the procedure of Example 40 to give the title compound.

Quellen und Nachweise

ORD-Eintrag: ord-57f00b94c4814514bfd753509962c448
Quelldatensatz: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04293697

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