N-ethyl-N'-[2-(2-pyrazinylmethylamino)ethyl]thiourea → N-cyano-N'-ethyl-N"-[2-(2-pyrazinylmethylamino)ethyl]-guanidine

HRID 847969

Reaktionsgleichung

Reaktionsgleichung von HRID 847969
[CH2:1]([NH:3][C:4]([NH:6][CH2:7][CH2:8][NH:9][CH2:10][C:11]1[CH:16]=[N:15][CH:14]=[CH:13][N:12]=1)=S)[CH3:2].[N:17]#[C:18][NH2:19].[Pb]>>[C:18]([NH:19][C:4]([NH:3][CH2:1][CH3:2])=[N:6][CH2:7][CH2:8][NH:9][CH2:10][C:11]1[CH:16]=[N:15][CH:14]=[CH:13][N:12]=1)#[N:17]

Komponenten

3

Edukt 2

HCID 20567640N-ethyl-N'-[2-(2-pyrazinylmethylamino)ethyl]thioureaHCID 22262466CH2N2Pb

Produkt 1

HCID 54105532N-cyano-N'-ethyl-N"-[2-(2-pyrazinylmethylamino)ethyl]-guanidine

Versuchsvorschrift

Reacting N-(2-pyrazinylmethyl)ethylenediamine with ethyl isothiocyanate by the procedure of Example 3 and chromatographing gives N-ethyl-N'-[2-(2-pyrazinylmethylamino)ethyl]thiourea. Reacting this thiourea with lead cyanamide by the procedure of Example 3 gives N-cyano-N'-ethyl-N"-[2-(2-pyrazinylmethylamino)ethyl]guanidine.

Quellen und Nachweise

ORD-Eintrag
ord-7855865b8044494e9000dfb7dc394f13
Quelldatensatz
uspto-grants-1981_10
Patentnummer
US04293699

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