Sodium Carbonate → 3-[[2-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-oxoethyl]amino]benzamide

HRID 848729Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 848729
Cl.[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3].C(=O)([O-])[O-].[Na+].[Na+].Cl.C(C1C=C(NCC(NC2C=CC(OC)=C(OC)C=2)=O)C=CC=1)(=O)N>C(Cl)(Cl)Cl>[C:2]([C:5]1[CH:6]=[C:7]([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[CH:19]=2)=[O:14])[CH:8]=[CH:9][CH:10]=1)(=[O:4])[NH2:3]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 156650Benzamide, 3-((2-((2-(3,4-dimethoxyphenyl)ethyl)amino)-2-oxoethyl)amino)-, monohydrochlorideHCID 205642772-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenyl)acetamide hydrochloride

Produkt 1

HCID 1566513-[[2-[2-(3,4-Dimethoxyphenyl)ethylamino]-2-oxoethyl]amino]benzamideAusbeute 84,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To 3.0 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide hydrochloride were added 20 ml of a 5% aqueous sodium carbonate solution and 125 ml of chloroform, and the mixture was stirred at room temperature until the crystals of the above hydrochloride was completely dissolved. The chloroform layer was separated, washed with water, dried and the solvent was evaporated to dryness in vacuo. The residue was recrystallized from a mixture of methanol and diethyl ether to obtain 2.3 g of 2-(3-carbamoylphenylamino)-N-(3,4-dimethoxyphenethyl)acetamide having a melting point of 133°-135° C.

Aufarbeitung

  1. dissolutionwas completely dissolved
  2. customThe chloroform layer was separated
  3. washwashed with water
  4. customdried
  5. customthe solvent was evaporated to dryness in vacuo
  6. customThe residue was recrystallized from a mixture of methanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-9171c908778144788a069ebd956d8a64
Quelldatensatz
uspto-grants-1981_10
Patentnummer
US04297357

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