1(2H)-Phthalazinone → 4-[2-[1-Oxo-1,2-dihydrophthalazin-2-yl]ethoxy]benzaldehyde

HRID 849009

Reaktionsgleichung

Reaktionsgleichung von HRID 849009
[C:1]1(=[O:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][NH:2]1.Br[CH2:13][CH2:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1.C([O-])([O-])=O.[K+].[K+]>>[O:11]=[C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][N:2]1[CH2:13][CH2:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1

Komponenten

4

Edukt 3

HCID 83941(2H)-PhthalazinoneHCID 11430Potassium CarbonateHCID 2627064-(2-Bromoethoxy)Benzaldehyde

Produkt 1

HCID 111409394-[2-[1-Oxo-1,2-dihydrophthalazin-2-yl]ethoxy]benzaldehydeAusbeute 44 %

Versuchsvorschrift

##STR31## The title compound (700 mg, 44%) was prepared from 1(2H)-phthalazinone (800 mg, 5.48 mmol) (Ref: Chemistry of Heterocyclic Compounds; Condensed Pyridazines including Cinnolines and Phthalazines, edited by R. N. Castle; John Wiley and Sons, 27, (1973) 375-441), 4-[2-bromoethoxy]benzaldehyde (1.25 g, 5.48 mmol) and K2CO3 (1.5 g, 10.96 mmol) by a similar procedure to that described in preparation 2, mp: 104-106° C.

Aufarbeitung

  1. customthat described in preparation 2, mp: 104-106° C.

Quellen und Nachweise

ORD-Eintrag
ord-f5fcecb74d2c44a29148c8677187d255
Quelldatensatz
uspto-grants-2000_01
Patentnummer
US06011036

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