2-Methoxyaniline → HCID 19369805, Verbindung

4-Oxo-6-trifluoromethoxy-2,3,4,5-tetrahydrofuro[3,2-c]quinoline(272 mg, 1.0 mmol) was dissolved in diethylene glycol(10 ml), and 2-methoxyaniline(281 μl, 2.5 mmol) was added under nitrogen. The reaction mixture was refluxed at 250° C. for 15 hours. The reaction mixture was diluted in brine(20 ml), and the aqueous layer was extracted with dichloromethane(15 ml) for 3 times. The organic layer was washed with water(15 ml) for 3 times, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel chromatography with ethyl acetate as eleunt to obtain 298 mg of desired compound as solid in 76% of yield.

1. extractionthe aqueous layer was extracted with dichloromethane(15 ml) for 3 times
2. washThe organic layer was washed with water(15 ml) for 3 times
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by silica gel chromatography with ethyl acetate as eleunt

ORD-Eintrag

ord-56cc9630f82c4e6e842cf52b083e12bb

Quelldatensatz

uspto-grants-2000_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06011044