Potassium Iodide → 2-Acetonyloxy-4-chloro-3-fluoronitrobenzene

HRID 851083Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 851083
[Cl:1][C:2]1[C:3]([F:12])=[C:4]([OH:11])[C:5]([N+:8]([O-:10])=[O:9])=[CH:6][CH:7]=1.Cl[CH2:14][C:15](=[O:17])[CH3:16].[I-].[K+]>CC(C)=O>[CH2:14]([O:11][C:4]1[C:3]([F:12])=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9])[C:15]([CH3:16])=[O:17]

Komponenten

5

Edukt 3

HCID 4875Potassium IodideHCID 6571ChloroacetoneHCID 131885853-Chloro-2-fluoro-6-nitrophenol

Produkt 1

HCID 131885862-Acetonyloxy-4-chloro-3-fluoronitrobenzeneAusbeute 54,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 3 g (15.7 mmols) of 3-chloro-2-fluoro-6-nitrophenol, 3 ml of chloroacetone and 300 mg of potassium iodide in 50 ml of acetone was refluxed for 6 hours while vigorously stirring. After cooling, any insoluble substance was removed by filtration, and the filtrate was concentrated and purified by silica gel (20 g) column chromatography using chloroform as an eluant to provide 2.5 g (54.5% yield) of 2-acetonyloxy-4-chloro-3-fluoronitrobenzene as an oil.

Aufarbeitung

  1. temperaturewas refluxed for 6 hours
  2. temperatureAfter cooling
  3. customany insoluble substance was removed by filtration
  4. concentrationthe filtrate was concentrated
  5. custompurified by silica gel (20 g) column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e7ae9a4e404c437991836646a990e61b
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04382892

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