Methylamine → N-[[[2-[[5-(Dimethylaminomethyl)-3-thienylmethyl]thio]ethyl]amino](methylamino)methylene]methanesulphonamide

HRID 851113Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 851113
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:7]=[C:8]([CH2:11][N:12]([CH3:14])[CH3:13])[S:9][CH:10]=1.CS[C:17](=[N:20][S:21]([CH3:24])(=[O:23])=[O:22])SC.[CH3:25][NH2:26]>C(O)C>[CH3:13][N:12]([CH2:11][C:8]1[S:9][CH:10]=[C:6]([CH2:5][S:4][CH2:3][CH2:2][NH:1][C:17]([NH:26][CH3:25])=[N:20][S:21]([CH3:24])(=[O:23])=[O:22])[CH:7]=1)[CH3:14]

Komponenten

5

Edukt 3

HCID 6329MethylamineHCID 129265012-[(5-Dimethylaminomethyl-3-thienyl)methylthio]ethylamineHCID 13449843N-[bis(methylsulfanyl)methylidene]methanesulfonamide

Produkt 1

HCID 178485212N-[[[2-[[5-(Dimethylaminomethyl)-3-thienylmethyl]thio]ethyl]amino](methylamino)methylene]methanesulphonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 4-[[2-(amino)ethyl]thio]methyl-N,N-dimethyl-2-thiophenemethanamine (0.4 g) and S,S'-dimethyl-N- (methylsulphonyl)-dithio-carbonimidic acid (0.35 g) in ethanol (10 ml) was heated at 60° C. for 1 hour. A 33% solution of methylamine in ethanol (10 ml) was added and the mixture was stirred for 20 h. The solvent was evaporated in vacuo and the residue was purified by column chromatography on silica using methanol to give the title compound (0.5 g) as an amber gum.

Aufarbeitung

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was purified by column chromatography on silica

Quellen und Nachweise

ORD-Eintrag
ord-97646e3e2fd1497fba083247533837ea
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04382929

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