3,4-Dimethylphenol → 1,2,3,4-Tetrahydro-8,9-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one

Reaktionsgleichung

[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].Cl.O=[C:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH:13]1[C:18](OC)=[O:19]>>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]2[C:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=3[C:18](=[O:19])[O:9][C:4]=2[CH:3]=1

Komponenten

Edukt 2

HCID 72493,4-Dimethylphenol

HCID 2724028Methyl 4-oxopiperidine-3-carboxylate hydrochloride

Produkt 1

HCID 131369151,2,3,4-Tetrahydro-8,9-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-oneAusbeute 84,2 %

Versuchsvorschrift

Prepared by the method described in Example 1 from 3,4-dimethylphenol (10.0 g, 0.082 moles) and methyl 4-oxo-3-piperdinecarboxylate hydrochloride (11.3 g, 0.058 moles). Recrystallization from 2-methoxyethanol yielded the product (11.2 g), mp 172°-l74° C.

Aufarbeitung

customPrepared by the method
customRecrystallization from 2-methoxyethanol

Quellen und Nachweise

ORD-Eintrag: ord-298921b440f549e6bd10bc5587a43c75
Quelldatensatz: uspto-grants-1983_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04382939

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