3-(Trifluoromethyl)phenylglyoxal → N-(3-(4-Carbomethoxyphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine

HRID 851501

Reaktionsgleichung

Reaktionsgleichung von HRID 851501
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([C:9]([CH:11]=O)=[O:10])[CH:6]=[CH:7][CH:8]=1.[C:15]([C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([NH2:30])([CH3:29])[CH3:28])=[CH:21][CH:20]=1)([O:17][CH3:18])=[O:16]>>[C:15]([C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([NH:30][CH2:11][CH:9]([OH:10])[C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=2)([CH3:28])[CH3:29])=[CH:21][CH:20]=1)([O:17][CH3:18])=[O:16]

Komponenten

3

Edukt 2

HCID 27832843-(Trifluoromethyl)phenylglyoxalHCID 20501354Methyl 4-(3-amino-3-methylbutyl)benzoate

Produkt 1

HCID 20501353N-(3-(4-Carbomethoxyphenyl)-1,1-dimethylpropyl)-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine

Versuchsvorschrift

The title compound was prepared as in Example 1a from 3-trifluoromethylphenyl glyoxal (2.0 g) and 3-(4-carbomethoxyphenyl)-1,1-dimethylpropylamine (2.6 g) and isolated as the hydrochloride salt monohydrate m.p. 214°-219°. (methanol-ether). τ(DMSO d6) 8.6 (6H,s), 7.8-8.2 (2H,m), 6.6-7.4 (4H,m), 6.1 (3H,s), 5.8 (3H, broad, replaceable by D2O), 4.8 (1H,m), 2.55 (2H,d,J=8 Hz), 2.1-2.4 (4H,m), 2.07 (2H,d,J=8 Hz), 1.3 (1H, broad, replaceable by D2O), 0.33 (1H, broad, replaceable by D2O).

Quellen und Nachweise

ORD-Eintrag
ord-a6f25feab605470ea3374cce6f6bbb33
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04385066

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