Sodium Hydroxide → HCID 178484896, Verbindung

HRID 851749Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 851749
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.Cl.[CH3:14][N:15]=[CH:16]OCC.[OH-].[Na+]>C(O)C>[CH3:14][NH:15][CH:16]=[N:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 12210271ethyl N-methyl-formimidate hydrochlorideHCID 178507418HCID 178507418, Verbindung

Produkt 1

HCID 178484896HCID 178484896, VerbindungAusbeute 34,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 0.8 gm of 4-(4-aminophenyl)-1-H-imidazole and 1.86 gm of ethyl N-methyl-formimidate hydrochloride [F. H. Suydam et al., J. Org. Chem. 34, 292 (1969)] in 20 ml of anhydrous ethanol was stirred at room temperature for two days. The clear solution was evaporated to dryness, and the oily residue was dissolved in water. The solution so obtained was adjusted to pH 10 with 10% NaOH. The product which separated was extracted with ethyl acetate, the organic solution was evaporated to dryness, and the product obtained was purified through its hydorchloride salt to give 0.35 gm of the desired compound as crystalline solid.

Aufarbeitung

  1. customThe clear solution was evaporated to dryness
  2. dissolutionthe oily residue was dissolved in water
  3. customThe solution so obtained
  4. customThe product which separated
  5. extractionwas extracted with ethyl acetate
  6. customthe organic solution was evaporated to dryness
  7. customthe product obtained
  8. customwas purified through its hydorchloride salt

Quellen und Nachweise

ORD-Eintrag
ord-cab38a8cba5f443e9c9dd8e8e711905f
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04386099

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