Dimethyl Sulfoxide → HCID 54150769, Verbindung

HRID 851811Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 851811
C1(S([CH2:10][CH2:11][CH2:12][CH:13]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][C:14]2=O)(=O)=O)C=CC=CC=1.[OH-].[K+].CS(C)=O>C(O)C>[C:13]12[CH2:12][CH2:11][CH:10]=[C:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]=2

Komponenten

5

Edukt 3

HCID 679Dimethyl SulfoxideHCID 14797Potassium HydroxideHCID 205012032-[3-(Benzenesulfonyl)propyl]cyclododecan-1-one

Produkt 1

HCID 54150769HCID 54150769, VerbindungAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

0.728 g (2 mmole) of 2-(3-phenylsulfonyl-prop-1-yl)-cyclododecanone and 0.730 g (13 mmole) of KOH in solution in 10 ml of ethyl alcohol were heated to reflux for 1 hour. After addition of 2 ml of DMSO, the reaction mixture was heated to 120° and the excess of ethyl alcohol distilled therefrom. The resulting mixture was then heated at 110° for 12 hours, then treated as indicated hereinabove to afford 0.29 g (71% yield) of the desired compound.

Aufarbeitung

  1. temperatureto reflux for 1 hour
  2. temperaturethe reaction mixture was heated to 120°
  3. distillationthe excess of ethyl alcohol distilled
  4. temperatureThe resulting mixture was then heated at 110° for 12 hours
  5. additiontreated

Quellen und Nachweise

ORD-Eintrag
ord-2720ff0906c246c6872e647344fa83df
Quelldatensatz
uspto-grants-1983_05
Patentnummer
US04386220

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