Hydrochloric Acid → HCID 69198141, Verbindung

HRID 851904Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 851904
[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16]([O:18]C)=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1.Cl.[OH-:28].[Na+]>>[NH2:3][S:2]([C:7]1[CH:8]=[C:9]([CH:10]=[CH:11][C:6]=1[N:5]1[CH2:23][CH2:24][CH2:25][C:4]1=[O:28])[O:12][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=1)[C:16]([OH:18])=[O:17])(=[O:26])=[O:1]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69414424HCID 69414424, Verbindung

Produkt 1

HCID 69198141HCID 69198141, Verbindung

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

A suspension of the product obtained in Step A (1.1 g, 2.55 mmol) in 18 ml of 1N NaOH is heated at 95° C. until a solution is obtained. The solution is allowed to return to ambient temperature, is acidified with 1N HCl and extracted (CH2Cl2). The organic phases are combined, washed (saturated NaCl), dried (MgSO4) and evaporated. The residue is triturated in Et2O; the title product precipitates out and is recovered by filtration.

Aufarbeitung

  1. customis obtained
  2. customto return to ambient temperature
  3. extractionextracted (CH2Cl2)
  4. washwashed (saturated NaCl)
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customThe residue is triturated in Et2O
  8. customthe title product precipitates out
  9. filtrationis recovered by filtration

Quellen und Nachweise

ORD-Eintrag
ord-adc6694200354603bd574a2eea76fbad
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07253162B2

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