Methylamine → HCID 10157541, Verbindung

HRID 852028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 852028
[C:1]([C:3]1[C:4]([NH:20][C:21]2[CH:22]=[C:23]([CH:28]=[CH:29][C:30]=2[CH3:31])[C:24]([NH:26][CH3:27])=[O:25])=[N:5][C:6](S(C)(=O)=O)=[N:7][C:8]=1[N:9]([CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH3:10])#[N:2].[CH3:32][NH2:33]>O1CCOCC1>[C:1]([C:3]1[C:4]([NH:20][C:21]2[CH:22]=[C:23]([CH:28]=[CH:29][C:30]=2[CH3:31])[C:24]([NH:26][CH3:27])=[O:25])=[N:5][C:6]([NH:33][CH3:32])=[N:7][C:8]=1[N:9]([CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH3:10])#[N:2]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 10182026HCID 10182026, Verbindung

Produkt 1

HCID 10157541HCID 10157541, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

3-{5-Cyano-6-[(2,2-dimethyl-propyl)-methyl-amino]-2-methanesulfonyl-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide (44 mg, 0.1 mmol) and methylamine (1 mL, 1M in THF) were mixed in p-dioxane (1 mL) in a sealed tube. The mixture was heated to 80° C. for overnight. The solvent was removed in vacuo, and the product (23 mg) was purified by the silica gel column chromatography. MS (m/z): 396 (M+H).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe product (23 mg) was purified by the silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-2b0ac8780ca6421098097efb1d4276a0
Quelldatensatz
uspto-grants-2007_08
Patentnummer
US07253174B2

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